A source told ESPN’s Adam Schefter that Ertz suffered a high ankle sprain.
During his media availability Monday, coach Doug Pederson said he did not have any update on Ertz or Sanders but that he expected to have more information later in the day.
Ertz, a Pro Bowler each of the past three seasons, has 24 catches for 178 yards and a touchdown in 2020.
Sanders leads the Eagles with 434 rushing yards on 71 carries with three rushing touchdowns.
Pederson said the Eagles would likely use a running-back-by-committee approach if Sanders is unavailable to play.